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ANTIBACTERIAL RESISTANCE PATTERN IN ORGANISMS ISOLATED FROM SKIN AND SOFT TISSUE INFECTIONS IN CANCER PATIENTS: OBSERVATIONS FROM A TERTIARY CARE HOSPITAL

 

Ramakrishna Pai Jakribettu; Surlu Vidya Rao; Jessica Chavali; Jaffey Mary Mathew; Indu Parkavi; Manjeshwar Shrinath Baliga

 

ABSTRACT: Background: In recent years, bacterial infections have become a major problem and worse in immunocompromised cancer patients. The objective of this study was to observe for drug resistance pattern in bacteria isolated in infections of Skin and soft tissue in Cancer Patients (SSTI). Methods: This is a retrospective study and was carried out checking in to the medical records for 3 years (January 2009 to December 2011). The incidence and drug resistance pattern for various clinically used antibiotics against the isolated bacteria were analyzed. Results: A total of 395 cases of organisms were isolated. The gram negative bacteria accounted for 59.45% of the total culture positives. Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli were the most common gram positive and negative bacteria respectively. The isolates were resistant to most antibiotics with highest resistant being seen in the MRSA and the Multidrug resistant coagulase-negative staphylococci (MRCONS). However all isolates were sensitive to the new generation antibiotics Linezolid, Tigecycline, Daptomycin and Vancomycin. Conclusions: The study demonstrated that the bacteria studied had different resistance to most of the standard antibiotics. However all Gram negative organisms studied were sensitive to colistin, and Gram positive were sensitive to vancomycin, linezolid and teicoplanin

KEY WORDS: Cancer; Skin and soft tissue infections; Methicillin-resistant Staphylococcus aureus (MRSA) and Multidrug Resistant Coagulase-Negative Staphylococci (MRCONS)

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