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A RARE CASE REPORT OF PRIMARY SYNOVIAL SARCOMA OF KIDNEY

 

Kiran Agarwal, Neha Suman

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ABSTRACT: Synovial sarcoma represents 5-10% of all soft tissue sarcomas. It occurs primarily in the periarticular regions of extremities. Rarely this tumour has been reported in kidney. After extensive search of literature, less than 100 cases have been reported till date. It is difficult to diagnose this tumour because of its rarity and also because of its morphological resemblance to tumours like renal cell carcinoma with sarcomatoid differentiation, adult Wilms’ tumour, spindle cell carcinoma and metastatic sarcoma. Thorough histopathological examinations along with immunohistochemical markers are helpful in establishing the diagnosis. Here we present a case of a 27-year-old male who presented with right renal mass and was later diagnosed as primary synovial sarcoma of kidney. We also present a 10-year comprehensive review of the literature

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KEYWORD:  Kidney, rare, synovial sarcoma.

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REFERENCES:

  1. [1]. Weiss SW, Goldblum JR. Malignant soft tissue tumors of uncertain type. In: Weiss SW, Goldblum JR, eds. Enzinger and Weiss’s soft tissue tumors. 4th edition. St. Louis: MO: Mosby; 2001:1483-1565.

  2. [2]. Moch H, Humphrey PA, Ulbright TM, Victor E. WHO Classification of Tumours of the Urinary System and Male Genital Organs. 4th edition. IARC: Lyon; 2016: 61.

  3. [3]. Faria P, Argani P, Epstein J. Primary synovial sarcoma of the kidney: A molecular subset of so called embryonal renal sarcoma. Mod Pathol Am 1999; 12: 94.

  4. [4]. Wang J, Weiss LM, Hu B, Chu P, Zuppan C, Felix D, et al. Usefulness of  immunohistochemistry in delineating renal spindle cell tumours. A retrospective study of 31 cases. Histopathol 2004; 44: 462–1.

  5. [5]. Coindre JM, Pelmus M, Hostein I, Lussan C, Bui BN, Guillou L. Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 cases. Cancer 2003; 98: 2700-7.

  6. [6]. Bella AJ, Winquist EW, Perlman EJ.  Primary synovial sarcoma of the kidney diagnosed by molecular dectection of syt-ssx fusion transcripts. J Urol 2002; 168:1092-3.

  7. [7]. Ozkan EE, Mertsoylu H, Ozardali HI. A case of renal synovial sarcoma treated with adjuvant ifosfamide and doxorubicin. Intern Med 2011; 50:1575–80. 

  8. [8]. Takeshi N, Teruo I, Hiroshi U. Monophasic primary renal synovial sarcoma accompanied with a haemorrhagic cyst. Urol J 2011; 8: 244-7.

  9. [9]. Grampurohit VU, Myageri A, Rao RV. Primary renal synovial sarcoma. Urol Ann 2011; 3:110-3.

  10. [10]. Bakhshi GD, Khan AS, Shaikh AS, Khan MA, Khan MA, Jamadar NM. Primary renal synovial sarcoma. Clin Pract 2012; 30:44.

  11. [11]. Bhatkule MA, Dhawle MS, Kokandakar HR, Bindu RS. Primary renal synovial sarcoma: Report of a rare case. Clin Cancer Investig J 2013; 2: 353-5.

  12. [12]. Majumder A, Dey S, Khandakar B, Medda S, Chandra Paul P. Primary Renal Synovial Sarcoma: A Rare Tumor with an Atypical Presntation. Arch Iran Med 2014; 17: 726-8.

  13. [13]. Moorthy HK, Pillai BS, Varghese J. Primary Renal Synovial Sarcoma: An Oncologic Surprise. Urol Case Rep 2014; 2:152-3.

  14. [14]. Modi G, Madabhavi I, Panchal H, Anand A, Patel A, Parikh S, Revannasiddaiah S. Primary synovial sarcoma of kidney: a rare differential diagnosis of renomegaly. Case Rep Pathol 2014; 2014: 657497.

  15. [15]. Schoolmeester JK, Cheville JC, Folpe AL. Synovial sarcoma of the kidney: a clinicopathologic, immunohistochemical, and molecular genetic study of 16 cases. Am J Surg Pathol 2014; 38:60-5. 

  16. [16]. Abbas M, Dämmrich ME, Braubach P, Meinardus A, Kramer MW, Merseburger AS, et al. Synovial sarcoma of the kidney in a young patient with a review of the literature. Rare Tumors 2014; 6:5393.

  17. [17]. Wang Z, Zhong Z, Zhu L, Xiong W, Pan C, Wang X, et al."Primary synovial sarcoma of the kidney: A case report". Oncol Letters. 2015; 6: 3542-4. 

  18. [18]. Vedana M, Fuenfschilling M, Tzankov A, Zellweger T. Primary Synovial Cell Sarcoma of the Kidney: Case Report and Review of the Literature. Case Rep Oncol 2015; 8:128-2.

  19. [19]. Mishra S, Awasthi N, Hazra SP, Bera MK. Primary synovial sarcoma of the kidney. Saudi J Kidney Dis Transpl 2015; 26: 996-9.

  20. [20]. Köhle O, Abt D, Rothermundt C, Öhlschlegel C, Brugnolaro C, Schmid HP. Soft tissue sarcomas of the kidney. Rare Tumors 2015; 7:5635.

  21. [21]. Chandrasekaran D, Narayanaswamy K, Sundersingh S, Senniappan K, Raja A. Primary Synovial Sarcoma of the Kidney with Inferior Vena Caval Thrombus. Indian J Surg Oncol 2016; 7:345-8.

  22. [22]. Pathrose G, John NT, Hariharan P. Renal Synovial Sarcoma in a Young Pregnant Lady: A Case Report and Clinico-Pathological Profile. J Clin Diagn Res 2017; 11:13-4.

  23. [23]. Dutt UK, Manikandan R, Dorairajan LN, Srinivas BH. Biphasic renal synovial sarcoma with extensive venous tumor thrombosis: A rare presentation. Urol Ann 2018; 10:339-41.

  24. [24]. Tranesh G, Cortese C, Thiel D, Zhai QJ. Primary synovial sarcoma of the kidney-A case report and literature review. Int J Clin Exp Pathol 2018; 11: 2241-5.

  25. [25]. Huang Y, Liu D, Chen W. Primary renal synovial sarcoma: A case report and literature review. J Can Res Ther 2018; 14 Suppl S1: 267-9.

  26. [26]. Yellala A. Primary renal synovial sarcoma – a diagnostic dilemma. J Community Support Oncol 2018; 16: 202-5.

  27. [27]. Cao Z, Lu HZ, Feng XL. Primary renal synovial sarcoma: two cases and review of the literature. Int J Clin Exp Pathol 2018; 11:4346-1.

  28. [28]. El Chediak A, Mukherji D, Temraz S, Nassif S, Sinno S, Mahfouz R, et al. Primary synovial sarcoma of the kidney: a case report of complete pathological response at a Lebanese tertiary care center. BMC Urol 2018; 18:40.

  29. [29]. Pichler R, Heidegger I, Schachtner G, Stuehmeier J, Agaimy A, Maier H, et al. Renal rupture - Not what it seems. Urol Case Rep. 2017; 16:132-4.

  30. [30]. Stamm A, Conti N, Olgac S, Flores JP, Wagner MJ, Kozlowski P. Intraperitoneal Rupture of a Synovial Sarcoma of the Kidney. Rev Urol. 2019; 21(2-3):136-40.

  31. [31]. Cai HJ, Cao N, Wang W, Kong FL, Sun XX, Huang B. Primary renal synovial sarcoma: A case report. World J Clin Cases. 2019; 7(19):3098-3103. 

  32. [32]. Öztürk H. Prognostic features of renal sarcomas (Review). Oncol letters: 2015; 1034-8.

  33. [33]. Gabilondo F, Rodriquez F, Mohar A, Nuovo GJ, Domínguez-Malagón H. Primary synovial sarcoma of the kidney: corroboration with in situ polymerase chain reaction. Ann Diagn Pathol. 2008; 12:134–7.

  34. [34]. Park SJ, Kim HK, Kim CK, Park SK, Go ES, Kim ME, et al. A case of renal synovial sarcoma: complete remission was induced by chemotherapy with doxorubicin and ifosfamide. Korean J Intern Med. 2004; 19:62–5.

 To cite this article:

Agarwal K, Suman N. A rare case report of primary synovial sarcoma of kidney. Int. J. Med. Lab. Res. 2022; 7,2:34-40. http://doi.org/10.35503/IJMLR.2022.7206

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